Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
Rutgers, The State University of New Jersey · Cancer Institute of Florida · +9 more institutions
Abstract
Macroautophagy (autophagy hereafter) degrades and recycles proteins and organelles to support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and Ras-transformed cell lines require autophagy for mitochondrial function, stress survival, and engrafted tumor growth. Here, the essential autophagy gene autophagy-related-7 (atg7) was deleted concurrently with K-ras(G12D) activation in mouse models for non-small-cell lung cancer (NSCLC). atg7-deficient tumors accumulated dysfunctional mitochondria and prematurely induced p53 and proliferative arrest, which reduced tumor burden that was partly relieved by p53 deletion. atg7 loss altered tumor fate from adenomas and carcinomas to…
Citation impact
- FWCI
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- References
- 34
Authors
16- JYJessie Yanxiang GuoCorresponding
Rutgers, The State University of New Jersey, Cancer Institute of Florida, Rutgers Cancer Institute
- GKGizem Karsli-Uzunbas
Rutgers, The State University of New Jersey, New Jersey Institute of Technology, Cancer Institute of Florida, Rutgers Cancer Institute
- RMRobin Mathew
Rutgers, The State University of New Jersey, New Jersey Institute of Technology, Johnson University, Cancer Institute of Florida, Rutgers Cancer Institute
- SCSeena C. Aisner
Rutgers, The State University of New Jersey, New Jersey Institute of Technology, Cancer Institute of Florida, Rutgers Cancer Institute, Rutgers New Jersey Medical School
- JJJurre J. Kamphorst
Princeton University
Topics & keywords
- Autophagy
- Biology
- Mitochondrion
- Cancer research
- Carcinogenesis
- Oncogene
- Lipid droplet
- Programmed cell death