reviewArteriosclerosis Thrombosis and Vascular BiologyMar 18, 2009GREEN OA

The LDL Receptor

JLJoseph L. GoldsteinMSMichael S. Brown

The University of Texas Southwestern Medical Center

PubMed
Indexed incrossrefpubmed

Abstract

In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

Citation impact

1,317
total citations
FWCI
52.78
Percentile
100%
References
60
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • LDL receptor
  • Endocytosis
  • Receptor
  • Receptor-mediated endocytosis
  • Mechanism (biology)
  • Biology
  • Pharmacology
  • Cell biology
UN Sustainable Development Goals
  • Good health and well-being
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