Prospective evaluation of methylated  SEPT9  in plasma for detection of asymptomatic colorectal cancer

Church, Timothy R.; Wandell, Michael; Lofton–Day, Catherine; Mongin, Steven J.; Burger, Matthias; Payne, Shannon R.; Castaños‐Vélez, Esmeralda; Blumenstein, Brent A.; Rösch, Thomas; Osborn, Neal; Snover, Dale C.; Day, Robert; Ransohoff, David F.

doi:10.1136/gutjnl-2012-304149

articleGutFeb 13, 2013HYBRID OA

Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer

TRTimothy R. Church MWMichael Wandell CLCatherine Lofton–Day SJSteven J. Mongin MBMatthias Burger

University of Minnesota · Minnesota Department of Health · +9 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Background

As screening methods for colorectal cancer (CRC) are limited by uptake and adherence, further options are sought. A blood test might increase both, but none has yet been tested in a screening setting.

Objective

We prospectively assessed the accuracy of circulating methylated SEPT9 DNA (mSEPT9) for detecting CRC in a screening population.

Citation impact

803

total citations

FWCI: 24.38
Percentile: 100%
References: 46

Citations per year

Authors

13

Topics & keywords

Topics

Keywords

Medicine
Asymptomatic
Colorectal cancer
Colonoscopy
Internal medicine
Population
Blood test
Gastroenterology

UN Sustainable Development Goals

Good health and well-being

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