Identifying biological themes within lists of genes with EASE
Organogenesis (United States) · Science Applications International Corporation (United States) · +2 more institutions
Abstract
EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data. The biological themes returned by EASE recapitulate manually determined themes in previously published gene lists and are robust to varying methods of normalization, intensity calculation and statistical selection of genes. EASE is a powerful tool for rapidly converting the results of functional genomics studies from 'genes' to 'themes'.
Citation impact
- FWCI
- 52.57
- Percentile
- 100%
- References
- 35
Authors
5- DADouglas A HosackCorresponding
Organogenesis (United States)
- GDGlynn Dennis
Science Applications International Corporation (United States), Organogenesis (United States)
- BTBrad T. Sherman
Organogenesis (United States), Science Applications International Corporation (United States)
- HCH. Clifford Lane
National Institutes of Health, National Institute of Allergy and Infectious Diseases
- RARichard A. Lempicki
Science Applications International Corporation (United States), Organogenesis (United States)
Topics & keywords
- Biology
- Computational biology
- Genomics
- Human genetics
- Gene selection
- Normalization (sociology)
- Proteomics
- DNA microarray