Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

Ribic, Christine; Sargent, Daniel J.; Moore, Malcolm J.; Thibodeau, Stephen N.; French, Amy J.; Goldberg, Richard M.; Hamilton, Stanley R.; Laurent‐Puig, Pierre; Gryfe, Robert; Shepherd, Lois E.; Tu, Dongsheng; Redston, Mark; Gallinger, Steven

doi:10.1056/nejmoa022289

articleNew England Journal of MedicineJul 16, 2003BRONZE OA

Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer

CRChristine Ribic DJDaniel J. Sargent MJMalcolm J. Moore SNStephen N. Thibodeau AJAmy J. French

Lunenfeld-Tanenbaum Research Institute · Cancer Genetics (United States) · +6 more institutions

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Abstract

Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer.

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Topics & keywords

Topics

Keywords

Microsatellite instability
Hazard ratio
Medicine
Colorectal cancer
Internal medicine
Confidence interval
Fluorouracil
Oncology

UN Sustainable Development Goals

Good health and well-being

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