SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
Broad Institute · Brigham and Women's Hospital · +4 more institutions
Abstract
SUMMARY: The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies). AVAILABILITY: SNAP server is available at http://www.broad.mit.edu/mpg/snap/.
Citation impact
- FWCI
- 27.27
- Percentile
- 100%
- References
- 11
Authors
6- ADAndrew D. JohnsonCorresponding
Broad Institute, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Framingham Heart Study, Mass General Brigham
- RERobert E. Handsaker
Broad Institute, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Framingham Heart Study, Mass General Brigham
- SLSara L. Pulit
Broad Institute, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Framingham Heart Study, Mass General Brigham
- MMMarcia M. Nizzari
Broad Institute, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Framingham Heart Study, Mass General Brigham
- CJChristopher J. O’Donnell
Broad Institute, Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Framingham Heart Study, Mass General Brigham
Topics & keywords
- International HapMap Project
- Linkage disequilibrium
- Single-nucleotide polymorphism
- Annotation
- Identification (biology)
- Computer science
- Computational biology
- Tag SNP