Genome-Scale Reconstruction of the Saccharomyces cerevisiae Metabolic Network
University of California San Diego · Technical University of Denmark
Abstract
The metabolic network in the yeast Saccharomyces cerevisiae was reconstructed using currently available genomic, biochemical, and physiological information. The metabolic reactions were compartmentalized between the cytosol and the mitochondria, and transport steps between the compartments and the environment were included. A total of 708 structural open reading frames (ORFs) were accounted for in the reconstructed network, corresponding to 1035 metabolic reactions. Further, 140 reactions were included on the basis of biochemical evidence resulting in a genome-scale reconstructed metabolic network containing 1175 metabolic reactions and 584 metabolites. The number of gene functions included in the…
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Authors
5- JFJochen FörsterCorresponding
University of California San Diego, Technical University of Denmark
- IFIman Famili
University of California San Diego, Technical University of Denmark
- PFPatrick Fu
University of California San Diego, Technical University of Denmark
- BØBernhard Ø. Palsson
University of California San Diego, Technical University of Denmark
- JNJens Nielsen
University of California San Diego, Technical University of Denmark
Topics & keywords
- Saccharomyces cerevisiae
- Biology
- Metabolic network
- ORFS
- Computational biology
- Genome
- In silico
- Model organism