articleToxicological SciencesJan 6, 2005BRONZE OA

Comparative Study of the Endocrine-Disrupting Activity of Bisphenol A and 19 Related Compounds

SKShigeyuki Kitamura

Hiroshima University

PubMed
Indexed incrossrefpubmed

Abstract

The endocrine-disrupting activities of bisphenol A (BPA) and 19 related compounds were comparatively examined by means of different in vitro and in vivo reporter assays. BPA and some related compounds exhibited estrogenic activity in human breast cancer cell line MCF-7, but there were remarkable differences in activity. Tetrachlorobisphenol A (TCBPA) showed the highest activity, followed by bisphenol B, BPA, and tetramethylbisphenol A (TMBPA); 2,2-bis(4-hydroxyphenyl)-1-propanol, 1,1-bis(4-hydroxyphenyl)propionic acid and 2,2-diphenylpropane showed little or no activity. Anti-estrogenic activity against 17beta-estradiol was observed with TMBPA and tetrabromobisphenol A (TBBPA). TCBPA, TBBPA, and BPA gave…

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Topics & keywords

Topics
Keywords
  • Bisphenol A
  • Chemistry
  • Bisphenol
  • Endocrine disruptor
  • Tetrabromobisphenol A
  • In vivo
  • Internal medicine
  • Endocrinology
UN Sustainable Development Goals
  • Good health and well-being
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