Structure, function and diversity of the healthy human microbiome
Broad Institute · Harvard University · +68 more institutions
Abstract
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and early microbial exposure have all been implicated. Accordingly, to characterize the ecology of human-associated microbial communities, the Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far. We found the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals. The project…
Citation impact
- FWCI
- 227.30
- Percentile
- 100%
- References
- 29
Authors
271- CHCurtis HuttenhowerCorresponding
Broad Institute, Harvard University, Harvard University Press, Cancer Research And Biostatistics
- JFJ. Fah Sathirapongsasuti
Broad Institute, Harvard University, Cancer Research And Biostatistics
- NSNicola Segata
Howard Hughes Medical Institute, Harvard University, University of Colorado Boulder, Cancer Research And Biostatistics
- CHCurtis Huttenhower
Broad Institute, Harvard University, Washington University in St. Louis, Cancer Research And Biostatistics
- NJNiall J. Lennon
Broad Institute, J. Craig Venter Institute
Topics & keywords
- Microbiome
- Metagenomics
- Biology
- Ecology
- Human Microbiome Project
- Niche
- Human microbiome
- Community
Funding
- NSNational Science FoundationAwards: IIS-0812111, 1053486, DE-AC02-05CH11231, DBI-1053486, 0812111
- HHHoward Hughes Medical InstituteAward: DE-AC02-05CH11231
- UDU.S. Department of EnergyAwards: -AC02-05CH11231, Contract No. DE-AC02-05CH11231, 05CH11231, No. DE-AC02-05CH11231, AC02-05CH11231, DE-AC02, DE-AC02-05CH11231, DE-AC02-
- GAGordon and Betty Moore Foundation
- RURice University
- GIGladstone Institutes
- CACrohn's and Colitis Foundation
- CACrohn's and Colitis Foundation of Canada
- FWFonds Wetenschappelijk OnderzoekAward: DE-AC02-05CH11231
- VRVlaamse regering
- NINational Institutes of HealthAwards: U01HG004866, U54HG003067, U54HG004968, T32AI007528, U54HG003273, DBI-1053486, U54HG003079, U54HG004973, R01HG004885, P30DE020751, R21HG005811, DP2OD001500, DE-AC02-05CH11231, R01HG005969
- DTDefense Threat Reduction AgencyAwards: B104153I, DE-AC02-05CH11231, B084531I
- OOOffice of ScienceAwards: AC02-05CH11231, -AC02-05CH11231, DE-AC02, No. DE-AC02-05CH11231, Contract No. DE-AC02-05CH11231
- HHHorace H. Rackham School of Graduate Studies, University of Michigan
- UNU.S. National Library of Medicine
- DODivision of Biological InfrastructureAward: DBI-1053486
- ARArmy Research OfficeAwards: DE-AC02-05CH11231, W911NF-11-1-0473, W911NF, W911NF-11
- LALos Alamos National LaboratoryAward: DE-AC02-05CH11231