Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers
The University of Texas MD Anderson Cancer Center · Baylor College of Medicine · +2 more institutions
Abstract
Abstract The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To this end, we conducted comprehensive genomic analysis of gene expression, copy number, methylation, and point mutations in OSCC. Integrated analysis revealed more somatic events than previously reported, identifying four major driver pathways (mitogenic signaling, Notch, cell cycle, and TP53) and two additional key genes (FAT1, CASP8). The Notch pathway was defective in 66% of patients, and in follow-up studies of mechanism, functional NOTCH1 signaling inhibited proliferation of OSCC cell lines. Frequent…
Citation impact
- FWCI
- 25.49
- Percentile
- 100%
- References
- 44
Authors
25- CRCurtis R. Pickering
The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Baylor Genetics, Temple University
- JZJiexin Zhang
The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Baylor Genetics, Temple University
- SYSuk Young Yoo
The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Baylor Genetics, Temple University
- LBLinnéa Bengtsson
The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Baylor Genetics, Temple University
- SMShhyam Moorthy
The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Baylor Genetics, Temple University
Topics & keywords
- Biology
- Somatic cell
- Gene
- Cancer research
- Notch signaling pathway
- Head and neck squamous-cell carcinoma
- DNA methylation
- Cancer
- Good health and well-being