IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking
Harvard University · Massachusetts General Hospital · +2 more institutions
Abstract
IFN-gamma-inducible protein 10 (IP-10, CXCL10), a chemokine secreted from cells stimulated with type I and II IFNs and LPS, is a chemoattractant for activated T cells. Expression of IP-10 is seen in many Th1-type inflammatory diseases, where it is thought to play an important role in recruiting activated T cells into sites of tissue inflammation. To determine the in vivo function of IP-10, we constructed an IP-10-deficient mouse (IP-10(-/-)) by targeted gene disruption. Immunological analysis revealed that IP-10(-/-) mice had impaired T cell responses. T cell proliferation to allogeneic and antigenic stimulation and IFN-gamma secretion in response to antigenic challenge were impaired in IP-10(-/-) mice. In…
Citation impact
- FWCI
- 15.55
- Percentile
- 100%
- References
- 74
Authors
6- JDJennifer DufourCorresponding
Harvard University, Massachusetts General Hospital
- MDMichelle Dziejman
Harvard University, Massachusetts General Hospital
- MTMichael T. Liu
University of California, Irvine, Irvine University
- JHJosephine H. Leung
Harvard University, Massachusetts General Hospital
- TEThomas E. Lane
University of California, Irvine, Irvine University
Topics & keywords
- CXCL10
- Biology
- T cell
- Chemokine
- CD8
- Monokine
- Cytotoxic T cell
- Immunology