TGF-β superfamily members and ovarian follicle development
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Abstract
In recent years, exciting progress has been made towards unravelling the complex intraovarian control mechanisms that, in concert with systemic signals, coordinate the recruitment, selection and growth of follicles from the primordial stage through to ovulation and corpus luteum formation. A plethora of growth factors, many belonging to the transforming growth factor-beta (TGF-beta ) superfamily, are expressed by ovarian somatic cells and oocytes in a developmental, stage-related manner and function as intraovarian regulators of folliculogenesis. Two such factors, bone morphogenetic proteins, BMP-4 and BMP-7, are expressed by ovarian stromal cells and/or theca cells and have recently been implicated as…
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1,183
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Authors
2Topics & keywords
Topics
Keywords
- Folliculogenesis
- Biology
- Growth differentiation factor-9
- Growth differentiation factor
- Cell biology
- Endocrinology
- Corpus luteum
- Anti-Müllerian hormone
UN Sustainable Development Goals
- Good health and well-being
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