Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
Massachusetts Institute of Technology · Harvard University · +7 more institutions
Abstract
Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limited. Here, we report a three dimensional (3D) micromolding technique utilizing bioprinted agarose template fibers to fabricate microchannel networks with various architectural features within photocrosslinkable hydrogel…
Citation impact
- FWCI
- 44.04
- Percentile
- 100%
- References
- 50
Authors
11- LELuiz E. Bertassoni
Massachusetts Institute of Technology, Harvard University, University of Sydney, Brigham and Women's Hospital, Harvard–MIT Division of Health Sciences and Technology
- MCMartina Cecconi
Harvard University, Harvard–MIT Division of Health Sciences and Technology, Brigham and Women's Hospital, Massachusetts Institute of Technology
- VMVijayan Manoharan
Massachusetts Institute of Technology, Harvard University, Brigham and Women's Hospital, Harvard–MIT Division of Health Sciences and Technology
- MNMehdi Nikkhah
Massachusetts Institute of Technology, Harvard–MIT Division of Health Sciences and Technology, Harvard University, Brigham and Women's Hospital
- JHJesper Hjortnaes
Harvard–MIT Division of Health Sciences and Technology, Harvard University, Massachusetts Institute of Technology, Brigham and Women's Hospital
Topics & keywords
- Ethylene glycol
- Self-healing hydrogels
- Gelatin
- Tissue engineering
- Microchannel
- Biomedical engineering
- Materials science
- Agarose
- Clean water and sanitation