THE CARDIAC FIBROBLAST: Therapeutic Target in Myocardial Remodeling and Failure
Denver Health Medical Center · University of Colorado Health · +1 more institution
Abstract
Cardiac fibroblasts play a central role in the maintenance of extracellular matrix in the normal heart and as mediators of inflammatory and fibrotic myocardial remodeling in the injured and failing heart. In this review, we evaluate the cardiac fibroblast as a therapeutic target in heart disease. Unique features of cardiac fibroblast cell biology are discussed in relation to normal and pathophysiological cardiac function. The contribution of cardiac fibrosis as an independent risk factor in the outcome of heart failure is considered. Candidate drug therapies that derive benefit from actions on cardiac fibroblasts are summarized, including inhibitors of angiotensin-aldosterone systems, endothelin receptor…
Citation impact
- FWCI
- 18.03
- Percentile
- 100%
- References
- 137
Authors
4- RDR. Dale BrownCorresponding
Denver Health Medical Center, University of Colorado Health, University of Colorado Denver
- SKS. Kelly Ambler
Denver Health Medical Center, University of Colorado Health, University of Colorado Denver
- MDM. Darren Mitchell
Denver Health Medical Center, University of Colorado Health, University of Colorado Denver
- CSCarlin S. Long
Denver Health Medical Center, University of Colorado Health, University of Colorado Denver
Topics & keywords
- Heart failure
- Fibroblast
- Medicine
- Cardiac fibrosis
- Extracellular matrix
- Cardiac function curve
- Fibrosis
- Myocardial fibrosis
- Good health and well-being