Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Brigham and Women's Hospital · Harvard University · +21 more institutions
Abstract
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long "preclinical" phase of AD would provide a critical opportunity for therapeutic intervention; however, we need to further elucidate the link between the pathological cascade of AD and the emergence of clinical symptoms. The National Institute on Aging and the Alzheimer's Association convened an international workgroup to review the biomarker, epidemiological, and neuropsychological evidence, and to develop recommendations to determine the factors which best predict the risk of progression from "normal" cognition to mild cognitive impairment and AD dementia. We propose a…
Citation impact
- FWCI
- 221.31
- Percentile
- 100%
- References
- 71
Authors
21- RAReisa A. SperlingCorresponding
Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital
- PAPaul Aisen
University of California San Diego
- LBLaurel Beckett
University of California, Davis
- DADavid A. Bennett
Rush University Medical Center
- SCSuzanne Craft
University of Puget Sound, University of Washington, Geriatric Research Education and Clinical Center
Topics & keywords
- Disease
- Dementia
- Alzheimer's disease
- Workgroup
- Medicine
- Intervention (counseling)
- Psychology
- Neuropsychology
- Good health and well-being