Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
Karolinska University Hospital · Karolinska Institutet · +2 more institutions
Abstract
GLP-1 stimulates insulin secretion, suppresses glucagon secretion, delays gastric emptying, and inhibits small bowel motility, all actions contributing to the anti-diabetogenic peptide effect. Endothelial dysfunction is strongly associated with insulin resistance and type 2 diabetes mellitus and may cause the angiopathy typifying this debilitating disease. Therefore, interventions affecting both endothelial dysfunction and insulin resistance may prove useful in improving survival in type 2 diabetes patients. We investigated GLP-1's effect on endothelial function and insulin sensitivity (S(I)) in two groups: 1) 12 type 2 diabetes patients with stable coronary artery disease and 2) 10 healthy subjects with…
Citation impact
- FWCI
- 7.55
- Percentile
- 100%
- References
- 37
Authors
7Topics & keywords
- Medicine
- Internal medicine
- Endothelial dysfunction
- Insulin resistance
- Type 2 diabetes
- Coronary artery disease
- Endocrinology
- Insulin
- Good health and well-being