Biocompatibility, Biodistribution, and Drug‐Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals
California NanoSystems Institute · University of California, Los Angeles
Abstract
Mesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological, hematological, and histopathological examinations of blood samples and mouse tissues after MSN injection. Biodistribution studies using human cancer xenografts are carried out with in vivo imaging and fluorescent microscopy imaging, as well as with inductively coupled plasma mass spectroscopy. The results show that MSNs preferentially accumulate in tumors. Finally, the drug-delivery capability of MSNs is demonstrated by following tumor growth in mice treated with camptothecin-loaded MSNs. These results indicate that MSNs are…
Citation impact
- FWCI
- 41.03
- Percentile
- 100%
- References
- 51
Authors
5- JLJie Lü
California NanoSystems Institute
- MLMonty Liong
California NanoSystems Institute, University of California, Los Angeles
- ZLZongxi Li
California NanoSystems Institute, University of California, Los Angeles
- JIJeffrey I. Zink
California NanoSystems Institute, University of California, Los Angeles
- FTFuyuhiko TamanoiCorresponding
California NanoSystems Institute, University of California, Los Angeles
Topics & keywords
- Biodistribution
- Drug delivery
- Mesoporous silica
- Biocompatibility
- Camptothecin
- In vivo
- Materials science
- Nanoparticle
- Good health and well-being