The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury
Heidelberg University · University Hospital Heidelberg · +5 more institutions
Abstract
Data from the Women's Health Study show that serum levels of growth-differentiation factor-15 (GDF-15), a distant member of the transforming growth factor-beta superfamily, are an independent risk indicator for adverse cardiovascular events. However, the cellular sources, upstream regulators, and functional effects of GDF-15 in the cardiovascular system have not been elucidated. We have identified GDF-15 by cDNA expression array analysis as a gene that is strongly upregulated by nitrosative stress in cultured cardiomyocytes isolated from 1- to 3-day-old rats. GDF-15 mRNA and pro-peptide expression levels were also induced in cardiomyocytes subjected to simulated ischemia/reperfusion (I/R) via…
Citation impact
- FWCI
- 9.55
- Percentile
- 100%
- References
- 44
Authors
13- TKTibor KempfCorresponding
Heidelberg University, University Hospital Heidelberg, Medizinische Hochschule Hannover, Amsterdam University Medical Centers, University of Cincinnati, University of Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam
- MEMatthias Eden
Heidelberg University, University Hospital Heidelberg, Medizinische Hochschule Hannover, Amsterdam University Medical Centers, University of Cincinnati, University of Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam
- JSJens Strelau
Heidelberg University, University Hospital Heidelberg, Medizinische Hochschule Hannover, Amsterdam University Medical Centers, University of Cincinnati, University of Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam
- MNMarian Naguib
Heidelberg University, University Hospital Heidelberg, Medizinische Hochschule Hannover, Amsterdam University Medical Centers, University of Cincinnati, University of Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam
- CWChristian Willenbockel
Heidelberg University, University Hospital Heidelberg, Medizinische Hochschule Hannover, Amsterdam University Medical Centers, University of Cincinnati, University of Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam
Topics & keywords
- GDF15
- Autocrine signalling
- Ligation
- Growth differentiation factor
- Ischemia
- Internal medicine
- Paracrine signalling
- Endocrinology
- Good health and well-being