articleDiabetesDec 1, 2002BRONZE OA

Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes

JJJoseph J. SennPKPeter KloverINIrena NowakRARobert A. Mooney

University of Rochester

PubMed
Indexed incrossrefpubmed

Abstract

Interleukin (IL)-6 is one of several proinflammatory cytokines that have been associated with insulin resistance and type 2 diabetes. A two- to threefold elevation of circulating IL-6 has been observed in these conditions. Nonetheless, little evidence supports a direct role for IL-6 in mediating insulin resistance. Here, we present data that IL-6 can inhibit insulin receptor (IR) signal transduction and insulin action in both primary mouse hepatocytes and the human hepatocarcinoma cell line, HepG2. This inhibition depends on duration of IL-6 exposure, with a maximum effect at 1-1.5 h of pretreatment with IL-6 in both HepG2 cells and primary hepatocytes. The IL-6 effect is characterized by a decreased tyrosine…

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Authors

4

Topics & keywords

Topics
Keywords
  • Insulin resistance
  • Internal medicine
  • Endocrinology
  • Insulin
  • Insulin receptor substrate
  • Insulin receptor
  • IRS2
  • Glycogen synthase
UN Sustainable Development Goals
  • Good health and well-being
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