TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
MetroHealth Medical Center · Case Western Reserve University · +5 more institutions
Abstract
Historically, insulin resistance during pregnancy has been ascribed to increased production of placental hormones and cortisol. The purpose of this study was to test this hypothesis by correlating the longitudinal changes in insulin sensitivity during pregnancy with changes in placental hormones, cortisol, leptin, and tumor necrosis factor (TNF)-alpha. Insulin resistance was assessed in 15 women (5 with gestational diabetes mellitus [GDM] and 10 with normal glucose tolerance) using the euglycemic-hyperinsulinemic clamp procedure, before pregnancy (pregravid) and during early (12-14 weeks) and late (34-36 weeks) gestation. Body composition, plasma TNF-alpha, leptin, cortisol, and reproductive hormones (human…
Citation impact
- FWCI
- 16.47
- Percentile
- 100%
- References
- 48
Authors
8- JPJohn P. KirwanCorresponding
MetroHealth Medical Center, Case Western Reserve University
- SHSylvie Hauguel‐de Mouzon
Institut Cochin
- JLJ. Lepercq
Institut Cochin
- JCJean-Claude Challier
Hôpital Cochin, Hôpital Saint-Vincent-de-Paul
- LHLarraine Huston-Presley
MetroHealth Medical Center, Case Western Reserve University
Topics & keywords
- Endocrinology
- Internal medicine
- Human placental lactogen
- Insulin resistance
- Pregnancy
- Leptin
- Insulin
- Placental lactogen
- Good health and well-being