Hypoxia-Induced Angiogenesis: Good and Evil
Cancer Research Institute · UPMC Hillman Cancer Center · +2 more institutions
Abstract
The vascular network delivers oxygen (O(2)) and nutrients to all cells within the body. It is therefore not surprising that O(2) availability serves as a primary regulator of this complex organ. Most transcriptional responses to low O(2) are mediated by hypoxia-inducible factors (HIFs), highly conserved transcription factors that control the expression of numerous angiogenic, metabolic, and cell cycle genes. Accordingly, the HIF pathway is currently viewed as a master regulator of angiogenesis. HIF modulation could provide therapeutic benefit for a wide array of pathologies, including cancer, ischemic heart disease, peripheral artery disease, wound healing, and neovascular eye diseases. Hypoxia promotes vessel…
Citation impact
- FWCI
- 4.39
- Percentile
- 100%
- References
- 193
Authors
3- BLBryan L. KrockCorresponding
Cancer Research Institute, UPMC Hillman Cancer Center, University of Pennsylvania
- NSN. Skuli
Howard Hughes Medical Institute, Cancer Research Institute, UPMC Hillman Cancer Center, University of Pennsylvania
- MCM. Celeste Simon
Howard Hughes Medical Institute, Cancer Research Institute, UPMC Hillman Cancer Center, University of Pennsylvania
Topics & keywords
- Angiogenesis
- Hypoxia (environmental)
- Regulator
- Transcription factor
- Stromal cell
- Hypoxia-inducible factors
- Biology
- HIF1A
- Good health and well-being