articleNew England Journal of MedicineJul 6, 2005BRONZE OA

Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease

STSotirios TsimikasESEmmanouil S. BrilakisERElizabeth R. MillerJPJoseph P. McConnellRJRyan J. Lennon

University of California, San Diego · Mayo Clinic

PubMed
Indexed incrossrefpubmed

Abstract

Background

Lp(a) lipoprotein binds proinflammatory oxidized phospholipids. We investigated whether levels of oxidized low-density lipoprotein (LDL) measured with use of monoclonal antibody E06 reflect the presence and extent of obstructive coronary artery disease, defined as a stenosis of more than 50 percent of the luminal diameter.

Methods

Levels of oxidized LDL and Lp(a) lipoprotein were measured in a total of 504 patients immediately before coronary angiography. Levels of oxidized LDL are reported as the oxidized phospholipid content per particle of apolipoprotein B-100 (oxidized phospholipid:apo B-100 ratio).

Citation impact

766
total citations
FWCI
16.88
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100%
References
42
Citations per year

Authors

8

Topics & keywords

Topics
Keywords
  • Medicine
  • Lipoprotein
  • Proinflammatory cytokine
  • Coronary artery disease
  • Lipoprotein(a)
  • Internal medicine
  • Cardiology
  • Stenosis
UN Sustainable Development Goals
  • Good health and well-being
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