Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

Persaud, Deborah; Gay, Hannah; Ziemniak, Carrie; Chen, Ya Hui; Piatak, Michael; Chun, Tae‐Wook; Strain, Matthew C.; Richman, Douglas D.; Luzuriaga, Katherine

doi:10.1056/nejmoa1302976

articleNew England Journal of MedicineOct 23, 2013BRONZE OA

Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant

DPDeborah Persaud HGHannah Gay CZCarrie Ziemniak YHYa Hui Chen MPMichael Piatak

Johns Hopkins Medicine · Johns Hopkins University · +7 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.

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581

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Topics & keywords

Topics

Keywords

Medicine
Viremia
Antiretroviral therapy
Immunology
Human immunodeficiency virus (HIV)
Peripheral blood mononuclear cell
Persistence (discontinuity)
Pediatrics

UN Sustainable Development Goals

Good health and well-being

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