reviewFrontiers in ImmunologyOct 7, 2014GOLD OA

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

GAGuillermo Arango DuqueADAlbert Descoteaux

Institut National de la Recherche Scientifique

PubMed
Indexed incrossrefdoajpubmed

Abstract

The evolution of macrophages has made them primordial for both development and immunity. Their functions range from the shaping of body plans to the ingestion and elimination of apoptotic cells and pathogens. Cytokines are small soluble proteins that confer instructions and mediate communication among immune and non-immune cells. A portfolio of cytokines is central to the role of macrophages as sentries of the innate immune system that mediate the transition from innate to adaptive immunity. In concert with other mediators, cytokines bias the fate of macrophages into a spectrum of inflammation-promoting "classically activated," to anti-inflammatory or "alternatively activated" macrophages. Deregulated cytokine…

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Authors

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Topics & keywords

Topics
Keywords
  • Innate immune system
  • Cytokine
  • Inflammation
  • Biology
  • Immune system
  • Cell biology
  • Macrophage
  • Immunology
UN Sustainable Development Goals
  • Good health and well-being
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