A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma

Hoster, Eva; Dreyling, Martin; Hiddemann, Wolfgang; Gisselbrecht, Christian; Hoof, Achiel Van; Kluin‐Nelemans, Hanneke C.; Pfreundschuh, Michael; Reiser, Marcel; Metzner, Bernd; Einsele, Hermann; Peter, Norma; Jung, Wolfram; Wörmann, Bernhard; Ludwig, Wolfgang; Dührsen, Ulrich; Eimermacher, Hartmut; Wandt, Hannes; Hasford, Joerg; Hiddemann, Wolfgang; Unterhalt, Michael

doi:10.1182/blood-2007-06-095331

articleBloodOct 25, 2007Closed access

A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma

EHEva Hoster MDMartin Dreyling WHWolfgang Hiddemann CGChristian Gisselbrecht AVAchiel Van Hoof

Zimmer Biomet (Germany) · Christian-Albrechts-Universität zu Kiel · +15 more institutions

PubMed

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Abstract

There is no generally established prognostic index for patients with mantle cell lymphoma (MCL), because the International Prognostic Index (IPI) and Follicular Lymphoma International Prognostic Index (FLIPI) have been developed for diffuse large cell and follicular lymphoma patients, respectively. Using data of 455 advanced stage MCL patients treated within 3 clinical trials, we examined the prognostic relevance of IPI and FLIPI and derived a new prognostic index (MCL international prognostic index, MIPI) of overall survival (OS). Statistical methods included Kaplan-Meier estimates and the log-rank test for evaluating IPI and FLIPI and multiple Cox regression for developing the MIPI. IPI and FLIPI showed poor…

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Keywords

International Prognostic Index
Mantle cell lymphoma
Medicine
Follicular lymphoma
Internal medicine
Stage (stratigraphy)
Oncology
Proportional hazards model

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