Cascade Reactions in Multicompartmentalized Polymersomes
Radboud University Nijmegen · Centre National de la Recherche Scientifique · +6 more institutions
Abstract
Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments.
Citation impact
- FWCI
- 19.77
- Percentile
- 100%
- References
- 46
Authors
6- RJRuud J. R. W. Peters
Radboud University Nijmegen
- MMMaïté Marguet
Centre National de la Recherche Scientifique, Université de Bordeaux, Laboratoire de Chimie des Polymères Organiques
- SMSébastien Marais
Centre National de la Recherche Scientifique, Inserm, Neurocentre Magendie, Bordeaux Imaging Center
- MWMarco W. Fraaije
University of Groningen
- JCJan C. M. van HestCorresponding
Radboud University Nijmegen, Université de Bordeaux, Laboratoire de Chimie des Polymères Organiques
Topics & keywords
- Polymersome
- Nanoreactor
- Polybutadiene
- Chemistry
- Enzyme
- Polystyrene
- Cofactor
- Cascade reaction