Potential of fecal microbiota for early‐stage detection of colorectal cancer
European Molecular Biology Laboratory · European Molecular Biology Laboratory · +10 more institutions
Abstract
Several bacterial species have been implicated in the development of colorectal carcinoma (CRC), but CRC-associated changes of fecal microbiota and their potential for cancer screening remain to be explored. Here, we used metagenomic sequencing of fecal samples to identify taxonomic markers that distinguished CRC patients from tumor-free controls in a study population of 156 participants. Accuracy of metagenomic CRC detection was similar to the standard fecal occult blood test (FOBT) and when both approaches were combined, sensitivity improved > 45% relative to the FOBT, while maintaining its specificity. Accuracy of metagenomic CRC detection did not differ significantly between early- and late-stage cancer…
Citation impact
- FWCI
- 24.18
- Percentile
- 100%
- References
- 99
Authors
26- GZGeorg ZellerCorresponding
European Molecular Biology Laboratory, European Molecular Biology Laboratory
- JTJulien Tap
Université Paris-Est Créteil, Assistance Publique – Hôpitaux de Paris, European Molecular Biology Laboratory
- AYAnita Y. Voigt
German Cancer Research Center, Heidelberg University, University Hospital Heidelberg, National Center for Tumor Diseases, European Molecular Biology Laboratory
- SSShinichi Sunagawa
European Molecular Biology Laboratory, European Molecular Biology Laboratory
- JRJens Roat Kultima
European Molecular Biology Laboratory, European Molecular Biology Laboratory
Topics & keywords
- Metagenomics
- Biology
- Colorectal cancer
- Microbiome
- Feces
- Fecal occult blood
- Population
- Gut flora