Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
Howard Hughes Medical Institute · University of British Columbia · +9 more institutions
Abstract
UNLABELLED: Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using Next Generation RNA-sequencing and oligonucleotide arrays, we profiled 7 NEPC, 30 PCA, and 5 benign prostate tissue (BEN), and validated findings on tumors from a large cohort of patients (37 NEPC, 169 PCA, 22 BEN) using IHC and FISH. We discovered significant overexpression and gene amplification of AURKA and MYCN in 40% of NEPC and 5% of PCA, respectively, and evidence that that they cooperate to induce a neuroendocrine phenotype in prostate cells. There was dramatic and enhanced sensitivity of NEPC (and MYCN overexpressing PCA) to…
Citation impact
- FWCI
- 28.85
- Percentile
- 100%
- References
- 30
Authors
24- HBHimisha BeltranCorresponding
Howard Hughes Medical Institute, University of British Columbia, Inserm, University of Pittsburgh, University of Trento, Cornell University, University of Michigan, University Hospital Bonn, Yale University, Assistance Publique – Hôpitaux de Paris, Michigan Center for Translational Pathology
- DSDavid S. Rickman
Howard Hughes Medical Institute, University of British Columbia, Inserm, University of Pittsburgh, University of Trento, Cornell University, University of Michigan, University Hospital Bonn, Yale University, Assistance Publique – Hôpitaux de Paris, Michigan Center for Translational Pathology
- KPKyung Park
Howard Hughes Medical Institute, University of British Columbia, Inserm, University of Pittsburgh, University of Trento, Cornell University, University of Michigan, University Hospital Bonn, Yale University, Assistance Publique – Hôpitaux de Paris, Michigan Center for Translational Pathology
- SSSung Suk Chae
Howard Hughes Medical Institute, University of British Columbia, Inserm, University of Pittsburgh, University of Trento, Cornell University, University of Michigan, University Hospital Bonn, Yale University, Assistance Publique – Hôpitaux de Paris, Michigan Center for Translational Pathology
- ASAndrea Sboner
Howard Hughes Medical Institute, University of British Columbia, Inserm, University of Pittsburgh, University of Trento, Cornell University, University of Michigan, University Hospital Bonn, Yale University, Assistance Publique – Hôpitaux de Paris, Michigan Center for Translational Pathology
Topics & keywords
- Prostate cancer
- Cancer research
- Prostate
- Biology
- Aurora kinase
- Cancer
- Adenocarcinoma
- Neuroendocrine tumors
- Good health and well-being