Cucurbiturils: from synthesis to high-affinity binding and catalysis
University of Bremen · Constructor University
Abstract
In the wide area of supramolecular chemistry, cucurbit[n]urils (CBn) present themselves as a young family of molecular containers, able to form stable complexes with various guests, including drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocarbons, and even high molecular weight guests such as proteins (e.g., human insulin). Since the discovery of the first CBn, CB6, the field has seen tremendous growth with respect to the synthesis of new homologues and derivatives, the discovery of record binding affinities of guest molecules in their hydrophobic cavity, and associated applications ranging from sensing to drug delivery. In this review, we discuss in detail the…
Citation impact
- FWCI
- 49.77
- Percentile
- 100%
- References
- 240
Authors
2Topics & keywords
- Cucurbituril
- Supramolecular chemistry
- Chemistry
- Combinatorial chemistry
- Catalysis
- Small molecule
- Molecule
- Binding affinities