Cell intrinsic alterations underlie hematopoietic stem cell aging
Joslin Diabetes Center · Harvard University · +1 more institution
Abstract
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties of highly purified long-term hematopoietic stem cells (LT-HSCs) from young and old mice. We found that LT-HSC aging was accompanied by cell autonomous changes, including increased stem cell self-renewal, differential capacity to generate committed myeloid and lymphoid progenitors, and diminished lymphoid potential. Expression profiling revealed that LT-HSC aging was accompanied by the systemic down-regulation of…
Citation impact
- FWCI
- 15.92
- Percentile
- 100%
- References
- 47
Authors
7- DJDerrick J. RossiCorresponding
Joslin Diabetes Center, Harvard University, Stanford University
- DBDavid Bryder
Joslin Diabetes Center, Harvard University, Stanford University
- JMJacob M. Zahn
Joslin Diabetes Center, Harvard University, Stanford University
- HAHenrik Ahlenius
Joslin Diabetes Center, Harvard University, Stanford University
- RSRebecca Sonu
Joslin Diabetes Center, Harvard University, Stanford University
Topics & keywords
- Haematopoiesis
- Stem cell
- Myeloid
- Biology
- Progenitor cell
- Hematopoietic stem cell
- Myeloid leukemia
- Immune system
- Good health and well-being