Childhood maltreatment predicts adult inflammation in a life-course study
King's College London · Psychiatry Research Trust · +3 more institutions
Abstract
Stress in early life has been associated with insufficient glucocorticoid signaling in adulthood, possibly affecting inflammation processes. Childhood maltreatment has been linked to increased risk of adult disease with potential inflammatory origin. However, the impact of early life stress on adult inflammation is not known in humans. We tested the life-course association between childhood maltreatment and adult inflammation in a birth cohort followed to age 32 years as part of the Dunedin Multidisciplinary Health and Development Study. Regression models were used to estimate the effect of maltreatment on inflammation, adjusting for co-occurring risk factors and potential mediating variables. Maltreated…
Citation impact
- FWCI
- 41.79
- Percentile
- 100%
- References
- 45
Authors
5Topics & keywords
- Inflammation
- Medicine
- Life course approach
- Relative risk
- C-reactive protein
- Population
- Poison control
- Young adult
- No poverty