Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
University of Ulster · Friedrich-Alexander-Universität Erlangen-Nürnberg · +6 more institutions
Abstract
We examined whether neuronal proteinase-activated receptor-2 (PAR-2) may be involved in pruritus of human skin. The endogenous PAR-2 agonist tryptase was increased up to fourfold in atopic dermatitis (AD) patients. PAR-2 was markedly enhanced on primary afferent nerve fibers in skin biopsies of AD patients. Intracutaneous injection of endogenous PAR-2 agonists provoked enhanced and prolonged itch when applied intralesionally. Moreover, itch upon mast cell degranulation was abolished by local antihistamines in controls but prevailed in AD patients. Thus, we identified enhanced PAR-2 signaling as a new link between inflammatory and sensory phenomena in AD patients. PAR-2 therefore represents a promising…
Citation impact
- FWCI
- 20.84
- Percentile
- 100%
- References
- 41
Authors
8- MSMartin SteinhoffCorresponding
University of Ulster, Friedrich-Alexander-Universität Erlangen-Nürnberg
- UNUlrich Neisius
Friedrich-Alexander-Universität Erlangen-Nürnberg, Heidelberg University, Universitätsklinikum Erlangen
- AIAkihiko Ikoma
Heidelberg University
- MFManigé Fartasch
Friedrich-Alexander-Universität Erlangen-Nürnberg, Heidelberg University, Universitätsklinikum Erlangen
- GHG. Heyer
Friedrich-Alexander-Universität Erlangen-Nürnberg, Heidelberg University, Universitätsklinikum Erlangen
Topics & keywords
- Degranulation
- Tryptase
- Endogeny
- Medicine
- Atopic dermatitis
- Receptor
- Neurogenic inflammation
- Mast cell
- Good health and well-being