articleNucleic Acids ResearchDec 15, 2007GOLD OA

STITCH: interaction networks of chemicals and proteins

European Molecular Biology Laboratory · University of Zurich

PubMed
Indexed incrossrefdoajpubmed

Abstract

The knowledge about interactions between proteins and small molecules is essential for the understanding of molecular and cellular functions. However, information on such interactions is widely dispersed across numerous databases and the literature. To facilitate access to this data, STITCH ('search tool for interactions of chemicals') integrates information about interactions from metabolic pathways, crystal structures, binding experiments and drug-target relationships. Inferred information from phenotypic effects, text mining and chemical structure similarity is used to predict relations between chemicals. STITCH further allows exploring the network of chemical relations, also in the context of associated…

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1,003
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Authors

5

Topics & keywords

Keywords
  • Biology
  • Context (archaeology)
  • Interaction information
  • Computational biology
  • Interaction network
  • Genome
  • Chemical similarity
  • Similarity (geometry)
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