A PINOID-Dependent Binary Switch in Apical-Basal PIN Polar Targeting Directs Auxin Efflux
Leiden University · University of Freiburg · +3 more institutions
Abstract
Polar transport-dependent local accumulation of auxin provides positional cues for multiple plant patterning processes. This directional auxin flow depends on the polar subcellular localization of the PIN auxin efflux regulators. Overexpression of the PINOID protein kinase induces a basal-to-apical shift in PIN localization, resulting in the loss of auxin gradients and strong defects in embryo and seedling roots. Conversely, pid loss of function induces an apical-to-basal shift in PIN1 polar targeting at the inflorescence apex, accompanied by defective organogenesis. Our results show that a PINOID-dependent binary switch controls PIN polarity and mediates changes in auxin flow to create local gradients for…
Citation impact
- FWCI
- 51.31
- Percentile
- 100%
- References
- 21
Authors
13- JFJiřı́ Friml
Leiden University, University of Freiburg, Peking University, Umeå Plant Science Centre, University of Tübingen
- XYXiong Yang
Leiden University, University of Freiburg, Peking University, Umeå Plant Science Centre, University of Tübingen
- MMMarta Michniewicz
Leiden University, University of Freiburg, Peking University, Umeå Plant Science Centre, University of Tübingen
- DWDolf Weijers
Leiden University, University of Freiburg, Peking University, Umeå Plant Science Centre, University of Tübingen
- AQAb Quint
Leiden University, University of Freiburg, Peking University, Umeå Plant Science Centre, University of Tübingen
Topics & keywords
- Auxin
- Polar auxin transport
- Cell biology
- Biology
- Polarity (international relations)
- Apex (geometry)
- Basal (medicine)
- Biophysics
- Life in Land