IFI16 is an innate immune sensor for intracellular DNA
Trinity College Dublin · Aarhus University · +4 more institutions
Abstract
Foreign nucleic acids trigger innate immune sensors. Bowie and colleagues identify the PYHIN protein IFI16 as an innate duplex DNA sensor that triggers IFN-β production in a STING-TBK1-IRF3 signaling pathway. The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β). IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by…
Citation impact
- FWCI
- 38.95
- Percentile
- 100%
- References
- 42
Authors
13Topics & keywords
- IRF3
- AIM2
- Innate immune system
- Biology
- DNA
- Interferon
- Stimulator of interferon genes
- Cell biology
Funding
- DODivision of Intramural Research, National Institute of Allergy and Infectious DiseasesAward: AI067497
- UOUniversity of Miami
- SOSundhed og Sygdom, Det Frie ForskningsrådAward: 09-072636
- YUYork University
- SFScience Foundation Ireland
- TCTrinity College Dublin
- LLundbeckfonden
- UOUniversity of Toronto
- HLH. Lundbeck A/S
- NINational Institutes of HealthAwards: AI067497, AI067497 to K.A.F, AI083713
- MRMedical Research Council
- NINational Institute of Allergy and Infectious DiseasesAwards: AI083713, AI067497
- NDNHLBI Division of Intramural Research