articleBioinformaticsFeb 12, 2003BRONZE OA

Multifactor dimensionality reduction software for detecting gene–gene and gene–environment interactions

LWLance W. HahnMDMarylyn D. RitchieJHJason H. Moore

Vanderbilt University · Vanderbilt University Medical Center

PubMed
Indexed incrossrefdoajpubmed

Abstract

MOTIVATION: Polymorphisms in human genes are being described in remarkable numbers. Determining which polymorphisms and which environmental factors are associated with common, complex diseases has become a daunting task. This is partly because the effect of any single genetic variation will likely be dependent on other genetic variations (gene-gene interaction or epistasis) and environmental factors (gene-environment interaction). Detecting and characterizing interactions among multiple factors is both a statistical and a computational challenge. To address this problem, we have developed a multifactor dimensionality reduction (MDR) method for collapsing high-dimensional genetic data into a single dimension…

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Topics & keywords

Topics
Keywords
  • Multifactor dimensionality reduction
  • Executable
  • Computer science
  • Epistasis
  • Dimensionality reduction
  • Software
  • Data mining
  • Documentation
UN Sustainable Development Goals
  • Life in Land
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