Rapid DNA Methylation Changes after Exposure to Traffic Particles
Harvard University · University of Milan · +6 more institutions
Abstract
We evaluated whether particulate pollution modifies DNA methylation in heavily methylated sequences with high representation throughout the human genome.
We measured DNA methylation of long interspersed nucleotide element (LINE)-1 and Alu repetitive elements by quantitative polymerase chain reaction-pyrosequencing of 1,097 blood samples from 718 elderly participants in the Boston area Normative Aging Study. We used covariate-adjusted mixed models to account for within-subject correlation in repeated measures. We estimated the effects on DNA methylation of ambient particulate pollutants (black carbon, particulate matter with aerodynamic diameter 0.12).
Citation impact
- FWCI
- 23.41
- Percentile
- 100%
- References
- 92
Authors
10- ABAndrea BaccarelliCorresponding
Harvard University, University of Milan, Ospedale Maggiore
- RORobert O. Wright
Brigham and Women's Hospital, Harvard University, Harvard University Press
- VBValentina Bollati
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Ospedale Maggiore
- LTLetizia Tarantini
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Ospedale Maggiore
- AAAugusto A. Litonjua
Brigham and Women's Hospital, Harvard University, Harvard University Press
Topics & keywords
- DNA methylation
- Particulates
- Methylation
- Medicine
- Oxidative stress
- Alu element
- Inhalation exposure
- Internal medicine
- Good health and well-being