hERG K + Channels: Structure, Function, and Clinical Significance
University of Ottawa · Victor Chang Cardiac Research Institute · +2 more institutions
Abstract
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are expressed in the heart, various brain regions, smooth muscle cells, endocrine cells, and a wide range of tumor cell lines. However, it is the role that Kv11.1 channels play in the heart that has been best characterized, for two main reasons. First, it is the gene product involved in chromosome 7-associated long QT syndrome (LQTS), an inherited disorder associated with a markedly increased risk of ventricular arrhythmias and sudden cardiac death. Second, blockade of Kv11.1, by a wide range of prescription medications, causes drug-induced QT prolongation…
Citation impact
- FWCI
- 23.05
- Percentile
- 100%
- References
- 748
Authors
6- JIJamie I. VandenbergCorresponding
University of Ottawa, Victor Chang Cardiac Research Institute, UNSW Sydney, St Vincent's Clinic
- MPMatthew Perry
University of Ottawa, Victor Chang Cardiac Research Institute, UNSW Sydney, St Vincent's Clinic
- MJMark J. Perrin
University of Ottawa, Victor Chang Cardiac Research Institute, UNSW Sydney, St Vincent's Clinic
- SAStefan A. Mann
University of Ottawa, Victor Chang Cardiac Research Institute, UNSW Sydney, St Vincent's Clinic
- YKYing Ke
University of Ottawa, Victor Chang Cardiac Research Institute, UNSW Sydney, St Vincent's Clinic
Topics & keywords
- hERG
- Short QT syndrome
- Sudden death
- Long QT syndrome
- QT interval
- Potassium channel
- Sudden cardiac death
- Internal medicine
- Good health and well-being