Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

The long-term health of the cell is inextricably linked to protein quality control. Under optimal conditions this is accomplished by protein homeostasis, a highly complex network of molecular interactions that balances protein biosynthesis, folding, translocation, assembly/disassembly, and clearance. This review will examine the consequences of an imbalance in homeostasis on the flux of misfolded proteins that, if unattended, can result in severe molecular damage to the cell. Adaptation and survival requires the ability to sense damaged proteins and to coordinate the activities of protective stress response pathways and chaperone networks. Yet, despite the abundance and apparent capacity of chaperones and…

• AA
  ALS Association
• NI
  National Institutes of Health
• NI
  National Institute on Aging
• NI
  National Institute of General Medical Sciences
• NI
  National Institute of Neurological Disorders and Stroke