articleNew England Journal of MedicineMar 26, 2012BRONZE OA

Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days

McMaster University · Hamilton Health Sciences · +17 more institutions

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Abstract

Background

The relative benefits and risks of performing coronary-artery bypass grafting (CABG) with a beating-heart technique (off-pump CABG), as compared with cardiopulmonary bypass (on-pump CABG), are not clearly established.

Methods

At 79 centers in 19 countries, we randomly assigned 4752 patients in whom CABG was planned to undergo the procedure off-pump or on-pump. The first coprimary outcome was a composite of death, nonfatal stroke, nonfatal myocardial infarction, or new renal failure requiring dialysis at 30 days after randomization.

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