The extracellular matrix: A dynamic niche in cancer progression
University of California, San Francisco · Wellcome Centre for Cell-Matrix Research · +5 more institutions
Abstract
The local microenvironment, or niche, of a cancer cell plays important roles in cancer development. A major component of the niche is the extracellular matrix (ECM), a complex network of macromolecules with distinctive physical, biochemical, and biomechanical properties. Although tightly controlled during embryonic development and organ homeostasis, the ECM is commonly deregulated and becomes disorganized in diseases such as cancer. Abnormal ECM affects cancer progression by directly promoting cellular transformation and metastasis. Importantly, however, ECM anomalies also deregulate behavior of stromal cells, facilitate tumor-associated angiogenesis and inflammation, and thus lead to generation of a…
Citation impact
- FWCI
- 88.72
- Percentile
- 100%
- References
- 148
Authors
3- PLPengfei Lu
University of California, San Francisco, Wellcome Centre for Cell-Matrix Research, University of Manchester, Breakthrough, Division of Undergraduate Education, Cancer Research UK Manchester Institute, Biologie du Développement et Cellules Souches
- VMValerie M. Weaver
University of California, San Francisco, Division of Undergraduate Education, Biologie du Développement et Cellules Souches
- ZWZena WerbCorresponding
University of California, San Francisco, Division of Undergraduate Education, Biologie du Développement et Cellules Souches
Topics & keywords
- Extracellular matrix
- Biology
- Stromal cell
- Tumor microenvironment
- Cell biology
- Cancer cell
- Angiogenesis
- Cancer
- Good health and well-being