Once-Only Sigmoidoscopy in Colorectal Cancer Screening: Follow-up Findings of the Italian Randomized Controlled Trial--SCORE
European Institute of Oncology · Ospedale degli Infermi · +9 more institutions
Abstract
A single flexible sigmoidoscopy at around the age of 60 years has been proposed as an effective strategy for colorectal cancer (CRC) screening.
We conducted a randomized controlled trial to evaluate the effect of flexible sigmoidoscopy screening on CRC incidence and mortality. A questionnaire to assess the eligibility and interest in screening was mailed to 236,568 men and women, aged 55-64 years, who were randomly selected from six trial centers in Italy. Of the 56,532 respondents, interested and eligible subjects were randomly assigned to the intervention group (invitation for flexible sigmoidoscopy; n = 17,148) or the control group (no further contact; n = 17,144), between June 14, 1995, and May 10, 1999. Flexible sigmoidoscopy was performed on 9911 subjects. Intention-to-treat and per-protocol analyses were performed to compare the CRC incidence and mortality rates in the intervention and control groups. Per-protocol analysis was adjusted for noncompliance.
Citation impact
- FWCI
- 27.39
- Percentile
- 100%
- References
- 36
Authors
21- NSNereo SegnanCorresponding
European Institute of Oncology, Ospedale degli Infermi, Ospedale Policlinico San Martino, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Imperial College London, Azienda Ospedaliero Universitaria San Giovanni Battista, Candiolo Cancer Institute, Ospedale San Giovanni Antica Sede, Istituto per lo Studio e la Prevenzione Oncologica, ASL Roma, Piedmont Reference Center for Epidemiology and Cancer Prevention
- PAPaola Armaroli
Candiolo Cancer Institute, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, ASL Roma, Ospedale San Giovanni Antica Sede, Piedmont Reference Center for Epidemiology and Cancer Prevention, European Institute of Oncology, Azienda Ospedaliero Universitaria San Giovanni Battista, Istituto per lo Studio e la Prevenzione Oncologica, Ospedale Policlinico San Martino, Ospedale degli Infermi, Imperial College London
- LBL Bonelli
Imperial College London, Ospedale San Giovanni Antica Sede, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Candiolo Cancer Institute, European Institute of Oncology, ASL Roma, Piedmont Reference Center for Epidemiology and Cancer Prevention, Ospedale Policlinico San Martino, Azienda Ospedaliero Universitaria San Giovanni Battista, Ospedale degli Infermi, Istituto per lo Studio e la Prevenzione Oncologica
- MRMauro Risio
Candiolo Cancer Institute, Istituto per lo Studio e la Prevenzione Oncologica, Ospedale degli Infermi, ASL Roma, Ospedale Policlinico San Martino, Imperial College London, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Piedmont Reference Center for Epidemiology and Cancer Prevention, Ospedale San Giovanni Antica Sede, European Institute of Oncology, Azienda Ospedaliero Universitaria San Giovanni Battista
- SSStefania Sciallero
Ospedale San Giovanni Antica Sede, Imperial College London, Piedmont Reference Center for Epidemiology and Cancer Prevention, Ospedale Policlinico San Martino, Istituto per lo Studio e la Prevenzione Oncologica, European Institute of Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Ospedale degli Infermi, Candiolo Cancer Institute, ASL Roma, Azienda Ospedaliero Universitaria San Giovanni Battista
Topics & keywords
- Sigmoidoscopy
- Medicine
- Incidence (geometry)
- Randomized controlled trial
- Colorectal cancer
- Intervention (counseling)
- Internal medicine
- Colonoscopy
- Good health and well-being