Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
Philipps University of Marburg · Klinik und Poliklinik für Psychotherapie und Psychosomatik
Abstract
Constitutive activation of the FLT3 receptor tyrosine kinase, either by internal tandem duplication (ITD) of the juxtamembrane region or by point mutations in the second tyrosine kinase domain (TKD), has been described in patients with acute myelogenous leukemia (AML). We analyzed the prevalence and the potential prognostic impact of FLT3 mutations in 979 AML patients. Results were correlated with cytogenetic data and the clinical response. FLT3-ITD mutations were found in 20.4% and FLT3-TKD mutations in 7.7% of the patients. Each mutation was associated with similar clinical characteristics and was more prevalent in patients with normal karyotype. Significantly more FLT3 aberrations were found in patients…
Citation impact
- FWCI
- 23.74
- Percentile
- 100%
- References
- 61
Authors
12- CTChristian ThiedeCorresponding
Philipps University of Marburg, Klinik und Poliklinik für Psychotherapie und Psychosomatik
- CSChristine Steudel
Philipps University of Marburg, Klinik und Poliklinik für Psychotherapie und Psychosomatik
- BMBrigitte Mohr
Philipps University of Marburg, Klinik und Poliklinik für Psychotherapie und Psychosomatik
- MSMarkus Schaich
Philipps University of Marburg, Klinik und Poliklinik für Psychotherapie und Psychosomatik
- USUlrike Schäkel
Philipps University of Marburg, Klinik und Poliklinik für Psychotherapie und Psychosomatik
Topics & keywords
- Internal medicine
- Fms-Like Tyrosine Kinase 3
- Leukemia
- Mutation
- Mutant
- Point mutation
- Medicine
- Biology
- No poverty