Deciphering the transcriptional network of the dendritic cell lineage
Icahn School of Medicine at Mount Sinai · Mount Sinai Hospital · +6 more institutions
Abstract
The transcriptional regulation of commitment to the dendritic cell (DC) lineage and functional specialization of DCs in vivo is poorly understood. In this Resource, Merad and colleagues identify the lineage relationships among various tissue DC subsets. Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made a comprehensive comparative analysis of CD8+, CD103+, CD11b+ and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized…
Citation impact
- FWCI
- 32.97
- Percentile
- 100%
- References
- 66
Authors
20- JCJennifer C. MillerCorresponding
Icahn School of Medicine at Mount Sinai
- BDBrian D. Brown
Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital
- TSTal Shay
Broad Institute
- ELEmmanuel L. Gautier
Icahn School of Medicine at Mount Sinai, Washington University in St. Louis, Mount Sinai Hospital
- VJVladimir Jojic
Stanford University
Topics & keywords
- Biology
- Dendritic cell
- Lineage (genetic)
- Cell biology
- Progenitor cell
- Transcriptional regulation
- Function (biology)
- Myeloid