Global distribution and prevalence of hepatitis C virus genotypes
Oxford Research Group · University of Oxford · +4 more institutions
Abstract
UNLABELLED: Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations in genotype prevalence. This poses a challenge to the improved development of vaccines and pan-genotypic treatments, which require the consideration of global trends in HCV genotype prevalence. Here we provide the first comprehensive survey of these trends. To approximate national HCV genotype prevalence, studies published between 1989 and 2013 reporting HCV genotypes are reviewed and combined with overall HCV prevalence estimates from the Global Burden of Disease (GBD) project. We also generate regional and global genotype prevalence estimates, inferring data for countries lacking genotype information. We…
Citation impact
- FWCI
- 89.07
- Percentile
- 100%
- References
- 49
Authors
7- JPJane P. MessinaCorresponding
Oxford Research Group, University of Oxford
- IHIsla Humphreys
University of Oxford, Medawar Building for Pathogen Research
- ADAbraham D. Flaxman
Institute for Health Metrics and Evaluation
- ABAnthony Brown
University of Oxford, Medawar Building for Pathogen Research
- GCGraham Cooke
St Mary's Hospital, Imperial College London
Topics & keywords
- Genotype
- Hepatitis C virus
- Population
- Global health
- Virology
- Demography
- Medicine
- Biology