Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus
Consejo Superior de Investigaciones Científicas · Instituto de Productos Lácteos de Asturias · +2 more institutions
Abstract
UNLABELLED: Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease in humans and is characterized by the presence of hyperactive immune cells and aberrant antibody responses to nuclear and cytoplasmic antigens, including characteristic anti-double-stranded DNA antibodies. We performed a cross-sectional study in order to determine if an SLE-associated gut dysbiosis exists in patients without active disease. A group of 20 SLE patients in remission, for which there was strict inclusion and exclusion criteria, was recruited, and we used an optimized Ion Torrent 16S rRNA gene-based analysis protocol to decipher the fecal microbial profiles of these patients and compare them with those of…
Citation impact
- FWCI
- 13.23
- Percentile
- 100%
- References
- 62
Authors
13- AHArancha HeviaCorresponding
Consejo Superior de Investigaciones Científicas, Instituto de Productos Lácteos de Asturias
- CMChristian Milani
University of Parma
- PLPatricia López
Universidad de Oviedo
- ACAdriana Cuervo
Universidad de Oviedo
- SASilvia Arboleya
Consejo Superior de Investigaciones Científicas, Instituto de Productos Lácteos de Asturias
Topics & keywords
- Firmicutes
- Dysbiosis
- Immunology
- Systemic lupus erythematosus
- Bacteroidetes
- Microbiome
- Irritable bowel syndrome
- Immune system
- Reduced inequalities