Human Papillomavirus and Overall Survival After Progression of Oropharyngeal Squamous Cell Carcinoma
Johns Hopkins University · Moffitt Cancer Center · +1 more institution
Abstract
PURPOSE: Risk of cancer progression is reduced for patients with human papillomavirus (HPV) -positive oropharynx cancer (OPC) relative to HPV-negative OPC, but it is unknown whether risk of death after progression is similarly reduced. PATIENTS AND METHODS: Patients with stage III-IV OPC enrolled onto Radiation Therapy Oncology Group trials 0129 or RTOG 0522 who had known tumor p16 status plus local, regional, and/or distant progression after receiving platinum-based chemoradiotherapy were eligible for a retrospective analysis of the association between tumor p16 status and overall survival (OS) after disease progression. Rates were estimated by Kaplan-Meier method and compared by log-rank; hazard ratios (HRs)…
Citation impact
- FWCI
- 40.00
- Percentile
- 100%
- References
- 39
Authors
13- CFCarole FakhryCorresponding
Johns Hopkins University, Moffitt Cancer Center
- QZQiang Zhang
Johns Hopkins University, Moffitt Cancer Center
- PFPhuc Félix Nguyen‐Tan
Johns Hopkins University, Moffitt Cancer Center, Université de Montréal
- DIDavid I. Rosenthal
Johns Hopkins University, Moffitt Cancer Center
- AKAdel K. El‐Naggar
Johns Hopkins University, Moffitt Cancer Center
Topics & keywords
- Medicine
- Human papillomavirus
- Basal cell
- Oncology
- Internal medicine
- Cancer research
- Good health and well-being