reviewAgingMar 10, 2011HYBRID OA

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

LSLinda S. SteelmanWHWilliam H. ChappellSLStephen L. AbramsCKChristian KempfJMJacquelyn M. Long

East Carolina University · Jagiellonian University · +11 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these…

Citation impact

699
total citations
FWCI
20.75
Percentile
100%
References
253
Citations per year

Authors

25

Topics & keywords

Topics
Keywords
  • PTEN
  • PI3K/AKT/mTOR pathway
  • MAPK/ERK pathway
  • Protein kinase B
  • Cancer research
  • Signal transduction
  • Biology
  • Crosstalk
UN Sustainable Development Goals
  • Good health and well-being
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