articleCirculationMar 30, 2004BRONZE OA

Left Cardiac Sympathetic Denervation in the Management of High-Risk Patients Affected by the Long-QT Syndrome

University of Helsinki · Peking University · +10 more institutions

PubMed
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Abstract

BACKGROUND: The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite beta-blockers is complex. We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in a group of high-risk patients. METHODS AND RESULTS: We identified 147 LQTS patients who underwent LCSD. Their QT interval was very prolonged (QTc, 543+/-65 ms); 99% were symptomatic; 48% had a cardiac arrest; and 75% of those treated with beta-blockers remained symptomatic. The average follow-up periods between first CE and LCSD and post-LCSD were 4.6 and 7.8 years, respectively. After LCSD, 46% remained asymptomatic. Syncope occurred in 31%, aborted cardiac arrest in 16%, and sudden death…

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680
total citations
FWCI
13.54
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100%
References
25
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Authors

18

Topics & keywords

Keywords
  • Medicine
  • Long QT syndrome
  • QT interval
  • Sympathetic Denervation
  • Cardiology
  • Internal medicine
  • Asymptomatic
  • Sudden cardiac death
UN Sustainable Development Goals
  • Good health and well-being
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