Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
Pohang University of Science and Technology · Catholic University of Korea · +2 more institutions
Abstract
The ability to print and pattern all the components that make up a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues is an exciting prospect of bioprinting. However, the majority of the matrix materials used so far for bioprinting cannot represent the complexity of natural extracellular matrix (ECM) and thus are unable to reconstitute the intrinsic cellular morphologies and functions. Here, we develop a method for the bioprinting of cell-laden constructs with novel decellularized extracellular matrix (dECM) bioink capable of providing an optimized microenvironment conducive to the growth of three-dimensional structured tissue. We show the versatility and…
Citation impact
- FWCI
- 66.92
- Percentile
- 100%
- References
- 58
Authors
8Topics & keywords
- Decellularization
- Extracellular matrix
- 3D bioprinting
- Matrix (chemical analysis)
- Cell biology
- Tissue engineering
- Process (computing)
- Regenerative medicine